Sogawa, H; Kubo, C
May 18, 2000
Mechanisms of Ageing and Development, vol. 115, no. 1–2, May 2000, pp. 61–71. PubMed, https://doi.org/10.1016/s0047-6374(00)00109-3.
Caloric restriction in rodents is well known to retard the rate of aging, increase mean and maximum life-spans, and inhibit the occurrence of many age-associated diseases. However, little is known about the influence of short-term repeated fasting on longevity. In this study, female (NZB x NZW)F1 mice were used to test the physiological effect of short-term repeated fasting (4 consecutive days, every 2 weeks). The results showed that fasting mice survived significantly longer than the full-fed mice, in spite of the fasting group having a heavier body weight than the control group. Mean survival times for fasting and control mice were 64.0+/-15.3 and 47.9+/-9.4 weeks, respectively. Short-term repeated fasting manipulation was also effective on the prolongation of life-span in autoimmune-prone mice.
Longevity, Aging, Intermittent Fasting
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