top of page

Growth Hormone Controls Lipolysis by Regulation of FSP27 Expression

Sharma R, Luong Q, Sharma VM, Harberson M, Harper B, Colborn A, Berryman DE, Jessen N, Jørgensen JOL, Kopchick JJ, Puri V, Lee KY

Dec 1, 2018

Journal of Endocrinology. 2018;239(3):289-301. doi:10.1530/JOE-18-0282

Abstract
Growth hormone (GH) has long been known to stimulate lipolysis and insulin resistance; however, the molecular mechanisms underlying these effects are unknown. In the present study, we demonstrate that GH acutely induces lipolysis in cultured adipocytes. This effect is secondary to the reduced expression of a negative regulator of lipolysis, fat-specific protein 27 (FSP27; aka Cidec) at both the mRNA and protein levels. These effects are mimicked in vivo as transgenic overexpression of GH leads to a reduction of FSP27 expression. Mechanistically, we show GH modulation of FSP27 expression is mediated through activation of both MEK/ERK- and STAT5-dependent intracellular signaling. These two molecular pathways interact to differentially manipulate peroxisome proliferator-activated receptor gamma activity (PPARγ) on the FSP27 promoter. Furthermore, overexpression of FSP27 is sufficient to fully suppress GH-induced lipolysis and insulin resistance in cultured adipocytes. Taken together, these data decipher a molecular mechanism by which GH acutely regulates lipolysis and insulin resistance in adipocytes.

Full Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226059/

Read Article

Diabetes, Metabolism, Obesity

Flexible Fasting.png

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only.  The content of this blog is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard, or delay in obtaining, medical advice for any medical condition they may have, and should seek the assistance of their health care professionals for any such conditions. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

  • Facebook
  • YouTube
  • Pinterest
  • Instagram

© 2021 by Flexible Fasting • All rights reserved • Created + Maintained by EmDesign

​

Privacy Policy • Legal Disclaimer  • Terms of Use • HSA/FSA Information

Kingdom Fasting Final Logo Feb Outlined.png
  • Facebook
  • YouTube
  • Instagram

© 2024 by Kingdom Fasting • All rights reserved • Created + Maintained by The Wix Collective

​

Privacy Policy • Legal Disclaimer  • Terms of Use 

The information on this website has not been evaluated by the Food and Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only.  The content of this blog is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard, or delay in obtaining, medical advice for any medical condition they may have, and should seek the assistance of their health care professionals for any such conditions. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

bottom of page